Précédent
Suivant
Brevet : EP1498421 - INHIBITEURS DE GAMMA SECRETASE
Titre
INHIBITEURS DE GAMMA SECRETASE
N° et date de publication de la demande
EP1498421 - 19/01/2005
Type de la demande
A1
N° et date de dépôt
EP03720938.4 - 18/04/2003
N° et date de priorité
JP2002121983 - 24/04/2002
Classification CIB
C07K 5/00 ; A61K 38/00 ; C07K 5/02 ; C07K 7/00 ; C07K 14/47 ; C07K 14/81 ; C07K 16/44 ; C12N 9/99
Classification CPC
A61K 38/00 ; C07K 5/0207 ; C07K 14/4711 ; C07K 14/8114 ; A61P 25/00 ; A61P 25/28 ; A61P 43/00 ; C07K 5/00 ; C07K 7/00 ; C07K 16/44 ; C07K 5/0207 ; C07K 14/8114 ; A61K 38/00 ; C07K 14/4711
Famille de brevets
NO329184B1 ; KR20040106370A ; WO03091278A1 ; JPWO2003091278A1 ; EP1498421A1 ; CN1656115A ; AU2003235283A1 ; US2006205666A1 ; BR0304562A ; ATE448242T1
Abrégé
Disclosed, as a gamma -secretase inhibitor, is a compound consisting of an amino acid sequence which consists of at least three consecutive amino acids of the amino acid sequence Val-Val-Ile-Ala-Thr-Val-Ile-Val-Ile-Thr-Leu-Val-Met-Leu-Lys-Lys-Lys including Leu at position 11, wherein, between the Leu and one or both amino acids located immediately before or after it, the peptide bond, -CO-NH-, is replaced with a hydroxyethylene group, -CHOH-CH2-, wherein the N terminus has an alkyloxycarbonyl group based on C1-10 alkyl that may carry phenyl or naphthyl as a substituent group, wherein the C terminus is converted to alkyl ester or alkyl amide based on C1-10 alkyl that may carry phenyl or naphthyl as a substituent group, and wherein the hydrogen atom of the hydroxyl group of the Thr at position 10 may be replaced with a C1-4 hydrophobic group or a Z group, or a pharmaceutically acceptable salt thereof.
INTERVENANTS
Déposant
MORI HIROSHI (MORI, HIROSHI) - JP
Titulaire
MORI, HIROSHI - ROOM 301, HAITSU-KOSUMO-21, 3-45, NAKAMICHI 1-CHOME, HIGASHINARI-KU OSAKA-SHI, OSAKA 537-0025 - JP
Inventeur
MORI, HIROSHI OSAKA-SHI, OSAKA 537-0025 - JP
Mandataire
CABINET MALEMONT C/O CABINET NETTER - 36 AVENUE HOCHE - 75008 PARIS - FR
STATUT EN FRANCE : Déchu
Délivrance
11/11/2009
Date de constatation de déchéance
-
31/12/2014 (BOPI 2015-04)
Dernière annuité payée
15/04/2013
Quantième- N° de l'annuité payée
11
Date de paiement de la prochaine annuité
30/04/2014
