Précédent
Suivant
Brevet : EP1305635 - PROCEDES D'IDENTIFICATION DE COMPOSES QUI MODULENT RAGE
Titre
PROCEDES D'IDENTIFICATION DE COMPOSES QUI MODULENT RAGE
N° et date de publication de la demande
EP1305635 - 02/05/2003
Type de la demande
A2
N° et date de dépôt
EP01941698.1 - 30/05/2001
N° et date de priorité
US20734200 - 30/05/2000 ; US79915201 - 05/03/2001
Classification CIB
G01N 33/50 ; G01N 33/68 ; A61K 38/00 ; A61K 45/00 ; A61K 48/00 ; A61P 3/10 ; A61P 13/12 ; A61P 15/10 ; A61P 25/28 ; A61P 29/00 ; A61P 35/00 ; A61P 43/00 ; G01N 33/15 ; G01N 33/53 ; G01N 33/543 ; G01N 33/566
Classification CPC
G01N 33/566 ; G01N2333/70503 ; A61P 13/12 ; A61P 15/10 ; A61P 25/28 ; A61P 29/00 ; A61P 35/00 ; A61P 43/00 ; A61P 3/10 ; G01N 33/566 ; G01N2333/70503
Famille de brevets
US2006078956A1 ; US6908741B1 ; ES2271028T3 ; EP1305635A2 ; DK1305635T3 ; CA2379521A1 ; JP2003535339A ; AU7502901A ; US2008293163A1 ; MXPA02001103A ; DE60123075T2 ; WO0192892A2 ; ATE339689T1
Abrégé
Provided are methods to detect of modulators of the Receptor for Advanced Glycated Endproducts (RAGE). The invention comprises a method for detection of RAGE modulators comprising: adsorbing a RAGE ligand onto a solid surface; adding a compound of interest and a protein comprising RAGE or fragment thereof, to the preadsorbed ligand; adding an antibody which binds to RAGE or fragment thereof and a secondary antibody which binds to the anti-RAGE antibody; measuring the secondary antibody bound to the anti-RAGE antibody; and comparing the amount of RAGE bound to the ligand in the presence of varying amounts of the compound of interest. In an embodiment, the fragment of RAGE is sRAGE. In one aspect, the invention use of compounds detected by the method for treatment of AGE-related syndromes including complications associated with diabetes, kidney failure, lupus nephritis or inflammatory lupus nephritis, amyloidoses, Alzheimer's disease, cancer, inflammation, and erectile dysfunction.
INTERVENANTS
Déposant
TRANS TECH PHARMA INC (TRANS TECH PHARMA, INC.) - US
Titulaire
Trans Tech Pharma, Inc.
Inventeur
SHAHBAZ MANOUCHEHR (SHAHBAZ, MANOUCHEHR) - US
Mandataire
BREVALEX - 95 RUE D'AMSTERDAM - 75378 PARIS CEDEX 8 - FR - N° Siren : 582120671
STATUT EN FRANCE : Déchu
Délivrance
13/09/2006
Remise de traduction du brevet
13/04/2007 (BOPI 2007-15)
Date de constatation de déchéance
-
30/01/2015 (BOPI 2015-09)
Dernière annuité payée
10/05/2013
Quantième- N° de l'annuité payée
13
Date de paiement de la prochaine annuité
02/06/2014
