Brevet : EP0850300 - PROCEDE DE MODULATION DE L'EXPRESSION D'UN GENE PROVOQUANT UNE REPONSE IMMUNOST...
Titre
PROCEDE DE MODULATION DE L'EXPRESSION D'UN GENE PROVOQUANT UNE REPONSE IMMUNOSTIMULATRICE REDUITE
N° et date de publication de la demande
EP0850300 - 01/07/1998
Type de la demande
A1
N° et date de dépôt
EP96923709.8 - 09/07/1996
N° et date de priorité
US51153695 - 04/08/1995
Classification CIB
A61K 31/00 ; A61K 31/70 ; A61K 31/7088 ; C12N 15/09 ; A61K 31/7125 ; A61K 48/00 ; A61P 31/00 ; A61P 35/00 ; C07H 21/00 ; C07H 21/04
Classification CPC
A61K 31/7125 ; C07H 21/00 ; A61P 31/00 ; A61P 35/00 ; A61K 31/7125 ; C07H 21/00
Famille de brevets
EP0850300A1 ; ATE185597T1 ; DE69604686T2 ; CA2229171A1 ; AU6455996A ; PT850300E ; WO9706253A1 ; GR3032357T3 ; ES2141516T3 ; US5968909A ; JPH11511014A
Abrégé
The present invention provides a method of reducing the immunostimulatory effects of certain phosphorothioate oligonucleotides used to treat pathogen-mediated disease states and other medical conditions. Immunostimulatory effects of phosphorothioate oligonucleotides are reduced in accordance with the method of the invention by modifying at least one chemical structure within the phosphorothioate oligonucleotide to produce an immunostimulatory response-reducing phosphorothioate oligonucleotide, which is then administered to a mammal afflicted with the disease or condition being treated. The immune response of the mammal is also monitored in the method of the invention.
INTERVENANTS
Déposant
HYBRIDON INC (HYBRIDON, INC.) - US
Titulaire
HYBRIDON, INC.
Inventeur
AGRAWAL SUDHIR (AGRAWAL, SUDHIR) - US
TEMSAMANI JAMAL (TEMSAMANI, JAMAL) - US
ZHAO QIUYAN (ZHAO, QIUYAN) - US
Mandataire
CABINET LEBOYER - 12 RUE DU HELDER - 75009 PARIS - FR - N° Siren : 352422760
STATUT EN FRANCE : Dossier expiré
Délivrance
13/10/1999
Remise de traduction du brevet
11/02/2000 (BOPI 2000-06)
Dernière annuité payée
17/07/2015
Quantième- N° de l'annuité payée
20