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Brevet : EP2066638 - PROCÉDÉ DE PURIFICATION DU MONTÉLUKAST
Titre
PROCÉDÉ DE PURIFICATION DU MONTÉLUKAST
N° et date de publication de la demande
EP2066638 - 10/06/2009
Type de la demande
A1
N° et date de dépôt
EP07788278.5 - 07/08/2007
N° et date de priorité
EP06118689 - 09/08/2006
Classification CIB
Classification CPC
Abrégé
It relates to a process for the purification of Montelukast, or pharmaceutically salts thereof, or solvates thereof, including stereoisomers or mixture thereof which comprises carrying out a specific set of selective solvent extractions of Montelukast or its impurities in a mixture of an organic solvent and water at specific ranges of pH and temperature which depend on the type of impurities to remove. In particular, it comprises at least one wash of an aqueous phase containing crude Montelukast in salt form with an organic solvent, at a pH comprised between 12.0 and 13.5; and optionally one or more washes of the resulting aqueous phase with an organic solvent at a pH comprised between 8.5 and 10.0. Montelukast is recovered by acidification at a pH comprised between 4.5 and 8.0 and solvent extraction, and is isolated either as acid or in salt form.
INTERVENANTS
Déposant
ESTEVE QUIMICA, S.A. - AVENIDA MARE DE DEU DE MONTSERRAT, 12 08024 BARCELONA - ES
Titulaire
ESTEVE QUIMICA, S.A. - AVENIDA MARE DE DEU DE MONTSERRAT, 12 08024 BARCELONA - ES
Inventeur
GASANZ GUILLEN, YOLANDA E-08024 BARCELONA - ES
MONSALVATJE LLAGOSTERA, MONTSERRAT E-08024 BARCELONA - ES
TALAVERA ESCASANY, PEDRO E-08024 BARCELONA - ES
Mandataire
CABINET BEAU DE LOMENIE - 158 RUE DE L UNIVERSITE - 75340 PARIS CEDEX 07 - FR - N° Siren : 775671076
STATUT EN FRANCE : Dossier déchu définitivement
Délivrance
23/02/2011
Date de constatation de déchéance
-
30/04/2013 (BOPI 2013-20)
Dernière annuité payée
09/08/2011
Quantième- N° de l'annuité payée
5
