Brevet : EP1286658 - AEROSOL A GOUTTELETTES LIQUIDES DE GAMMA-IFN ET PROCEDE ASSOCIE

Titre

AEROSOL A GOUTTELETTES LIQUIDES DE GAMMA-IFN ET PROCEDE ASSOCIE

N° et date de publication de la demande

EP1286658 - 05/03/2003

Type de la demande

A2

N° et date de dépôt

EP00992727.8 - 22/12/2000

N° et date de priorité

US17392699 - 30/12/1999

Famille de brevets

KR20020072563A ; CZ20022220A3 ; CN1434701A ; WO0149260A2 ; MXPA02006518A ; PL356817A1 ; US2001043906A1 ; HK1052876A1 ; JP2003519169A ; DE60026618T2 ; BR0016884A ; ZA200205167B ; NO20023135L ; CA2395803A1 ; EP1286658A2 ; ATE319424T1 ; AU4525801A ; NZ519773A

Abrégé

A liquid-droplet aerosol composition for delivery to a patient's respiratory tract is disclosed. The aerosol is formed by placing an aqueous gamma-IFN solution having stabilizing and dispersing components against a plate having defined-size openings, and forcing the solution through the openings under conditions effective to form aqueous droplets having a volume mean diameter in one or more of a number of selected sizes in the 1-10 micron size range. The aerosol has the desired-size droplets and a gamma-IFN biological activity and molecular size distribution substantially the same as that of the aqueous gamma-IFN solution. Also disclosed is a method of administering to a selected region of a patient's respiratory tract, an amount of human gamma-IFN having a known, selected gamma-interferon biological activity and molecular size distribution.